Daniel 8:8-9 says, "...the great horn was broken; and for it came up four notable ones toward the four winds of heaven. And out of one of them came forth a little horn..."

Antiochus - In Scripture, we typically don't see horns coming out of horns. The Bible says, "And then shall he send his angels, and shall gather together his elect FROM THE FOUR WINDS, from the uttermost part of the earth to the uttermost part of heaven." Mark 13:27. Again it says, "And their camels shall be a booty, and the multitude of their cattle a spoil: and I will scatter INTO ALL WINDS them that are in the utmost corners; and I will bring their calamity from all sides thereof, saith the LORD." Jeremiah 49:32. Horns don't arise out of horns; Horns arise from winds. Antiochus did not arise in the winds of strife.

Islam - emerged around 632 AD, however, this was long after the winds of strife died down from the divided Greek Empire. In essence, Islam did not arise from one of the winds of strife specifically referred to in Daniel chapter 8, because those winds no longer existed.

Papacy - The papacy did not emerge from the winds of strife, nor did it originate from the Greek Empire.

Imperial Rome - Rome entered the Greek Empire through warfare with Macedonia during the 3rd century BC. This war represented the winds of strife that the Little Horn arose from in verse 9.