In the original language, the word for Prince is śar This word, when referring to heavenly beings, always refers to Jesus. In Scripture, God is never known by śar. Thus, the Little Horn could only attack Christ through crucifixion or persecuting his Church. Looking at the context of where the Little Horn aligns within history, it's clear that the reference to Christ refers to the Christian Church and the dispensation of Christianity. Thus, the Little Horn couldn't be Antiochus due to the fact that Christianity didn't exist.